Scientific publications

D. Obrecht, E.Chevalier, K. Moehle, J.A. Robinson, Drug Disc. Today: Technologies 2012, 9, e63-e69; ß-Hairpin protein epitope mimetic technology in drug discovery.


M. Werneburg, K. Zerbe, M. Juhas, L. Bigler, U. Stalder, A. Kaech, U. Ziegler, D. Obrecht, L. Eberl, J. A. Robinson,ChemBioChem 201213, 1767-1775; Inhibition of Lipopolysaccharide Transport to the Outer Membrane in Pseudomonas aeruginosa by Peptidomimetic Antibiotics.


D. Obrecht, F. Bernardini, G. Dale, K. Dembowsky, Annual Reports Med. Chem. 201146, 245-262; Emerging New Therapeutics Against Key Gram-Negative Pathogens.


N. Srinivas, P. Jetter, B. J. Ueberbacher, M. Werneburg, K. Zerbe, J. Steinmann, B. Van der Meijden, F. Bernardini, A. Lederer, R. L. Dias, P. E. Misson, H. Henze, J. Zumbrunn, F. O. Gombert, D. Obrecht, P. Hunziker, S. Schauer, U. Ziegler, A. Käch, L. Eberl, K. Riedel, S. J. DeMarco, J. A. Robinson, Science 2010, 327, 1010-1013; Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa.


D. Obrecht, J. A. Robinson, F. Bernardini, C. Bisang, S. J. DeMarco, K. Moehle, F. O. Gombert, Curr. Med. Chem. 2009, 16, 42-65; Recent Progress in the Discovery of Macrocyclic Compounds as Potential Anti-Infective Therapeutics


J. A. Robinson, S. DeMarco, F. Gombert, K. Moehle, D. Obrecht, Drug Disc. Today 200813, 944-951; The design, structures and therapeutic potential of protein epitope mimetics.


A. Ernst, D. Obrecht, Case Studies of ParallelSynthesis in Hit Identification, Hit Exploration, Hit-to-Lead, and Lead Optimization Programs, Chapter 3, p.99-115; in High-Throughput Lead Optimization in Drug Discovery; Ed. T. Kshirsagar, CRC Press, 2008.


A. Lederer, S. J. DeMarco; H. Henze, B. Romagnoli, R. Mukherjee, J. Zumbrunn, F. Brianza, F. O. Gombert, C. Ludin, J. W. Vrijbloed, J.-P. Obrecht, S. Lociuro, V. Brondani, F. Hamy, T. Klimkait, K. Moehle, J. A. Robinson, D., Chimia 200761(4), 147-150. Discovery of highly potent and selective CXCR4 inhibitors using protein epitope mimetics (PEM) technology.


S. J. DeMarco, H. Henze, A. Lederer, K. Moehle, R. Mukherjee, B. Romagnoli, J. A. Robinson, F. Brianza, F. O. Gombert, S. Lociuro, Ch. Ludin, J.-W. Vrijbloed, J. Zumbrunn, J.-P. Obrecht, D. Obrecht, V. Brondani, F. Hamy, Th. Klimkait, Bioorg. Med. Chem. 200614, 8396-8404. Discovery of novel, highly potent and selective ß-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles.


R. Fasan, R. L. A. Dias, K. Moehle, O. Zerbe, D. Obrecht, P. E. Mittl, M. G. Grütter, J. A. Robinson, ChemBioChem 20067, 515-26. Structure-Activity Studies in a Family of ß-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.


R. L. Dias, R. Fasan, K. Moehle, A. Renard, D. Obrecht, J. A. Robinson, J. Am. Chem. Soc. 2006128, 2726-32; Protein Ligand Design: From Phage Display to Synthetic Protein Epitope Mimetics in Human Antibody Fc-Binding Peptidomimetics.


R. Fasan, R. L. A. Dias, K. Moehle, O. Zerbe, J. W. Vrijbloed, D. Obrecht, J. A. Robinson, Angew. Chem. 200443,2109-2112; Using a ß-hairpin to mimic an ?-helix: Cyclic peptidomimetics of the p53-HDM2 protein-protein interaction.


M. Altorfer, P. Ermert, J. Fässler, S. Farooq, E. Hillesheim, A. Jeanguenat, K. Klumpp, P. Maienfisch, J. A. Martin, J. H. Merrett, K. E. B. Parkes, J.-P. Obrecht, T. Pitterna, D. Obrecht, Chimia 200357, 262-269; Applications of Parallel Synthesis to Lead Optimization.