Chemokine receptor CXCR7
The chemokine receptor CXCR7 was indentified only very recently and its function is far from being fully understood. It is highly expressed in the endothelium of blood vessels and in various tumors. Like CXCR4, it binds SDF-1, but in addition it also binds ITAC. Since intracellular signaling could not unequivocally be demonstrated after ligand binding, it has been hypothesized that this receptor acts as a scavenger or decoy receptor controlling the extracellular concentration of its ligands.
By applying PEM Technology, Polyphor has identified two structurally diverse, highly potent and selective CXCR7 modulators which act as functional antagonists in various in vitro biological assays. In addition, the two lead compounds have favorable in vitro ADMET and in vivo PK properties. Polyphor therefore entered into collaborations with renowned academic partners in the field, who will use the compounds for pharmacological target validation in various models and thus support the selection of the most promising therapeutic applications.