Since 1996 Polyphor’s chemists have worked on numerous hit-to-lead and lead optimization programs in close collaboration with Pharma and Biotech companies. These programs covered a vast array of different types of molecules and chemistries. In addition, Polyphor chemists have designed and synthesized the Polyphor Library, a scaffold-rich, diverse high quality library for high throughput screening, which contains many novel scaffolds and for which several innovative synthesis approaches were developed. Hence, the experienced chemistry team at Polyphor has developed over time excellent problem solving skills which is one of the most important factors to run medicinal chemistry programs efficiently.
These strong design and synthesis capabilities were also at the heart of the development of Polyphor’s proprietary PEMfinder® and MacroFinder® Technology platforms. Both complementary platforms are based on macrocyclic molecules which are ideally suited to address challenging targets involving extra- and intracellular PPIs. The fully modular automated synthetic process allows for rapid iterative cycles of design, parallel synthesis and biological profiling of MacroFinder® and PEMfinder® libraries to efficiently optimize PK/PD properties of lead molecules. Medicinal chemistry at Polyphor is supported by a comprehensive set of state of the art internal ancillary capabilities.