MacroFinder® Library
MacroFinder® screening library characteristics
- Variable ring size (12-30, typically 12-18) with a molecular weight of 400-800 Dalton
- Semi-rigid backbone conformations induced by built-in structural constraints
- High degree of conformational fine tuning possible through variation of ring size and stereochemistry of modular building blocks
- Modular design allows efficient introduction of several privileged structural motifs
- MacroFinder® molecules show natural product-like structural complexity and exhibit small-molecule-like ADMET properties, in particular excellent cell penetration and oral bioavailability have been demonstrated
- Efficient production by automated parallel synthesis (mixed solid/solution phase synthesis)
- Systematic design and production of a diverse range of macrocyclic compounds. Currently, 8’000 MacroFinder® compounds are available for screening at Polyphor for drug discovery collaborations
Targets for MacroFinder®
MacroFinder® molecules are ideally suited to tackle difficult intracellular targets due to the above mentioned unique properties. In addition, depending on the target product profile, MacroFinder® compounds can be readily optimized to achieve oral bioavailability.
