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In vivo ADMET profiling

Pharmacokinetics (PK)

PK studies are most useful when performed early in the process of assessing a compound. Evaluation of the kinetics of compound plasma concentrations enable the prediction of physiological characteristics of an administered compound, like distribution, bioavailability, and overall elimination rates. These PK parameters can then be used for prediction of plasma concentrations for a given dose and route, allometric scaling, and other simulations to support the decision making process for subsequent in vivo studies.

At Polyphor no in vivo studies are performed in-house. All such studies are conducted in collaboration with specialized external partners who perform the in-life phase of the study (e.g. oral, intravascular, or subcutaneous dosing).

Once the in-life phase is completed, the compound concentration in diverse matrices (e.g. plasma, organs, and excrements), collected during the study, is determined by Polyphor’s in-house bioanalytic group.

Polyphor Ltd
Hegenheimermattweg 125
CH-4123 Allschwil
Switzerland
Tel. +41 61 567 16 00
Fax +41 61 567 16 01
info@polyphor.com

Last modified:   02.04.2013

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