Biostructural research/X-ray
Knowledge of the three-dimensional structure of protein targets is important for understanding their physical and functional properties. In particular, the detailed knowledge of intermolecular interactions with specific ligands revealed by the structure determination of complexes is essential for rationalizing affinity and specificity, key issues in the drug discovery and lead optimization process. Biostructural research at Polyphor, which takes advantage of the internally available infrastructure and of the access to the Swiss Light Source (SLS), Villigen, Switzerland, supports the lead identification and lead optimization process both for our internal and collaborative projects.



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