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Formyl peptide receptors FPR1/2

Formyl peptide receptors FPR1 and FPR2 belong to a class of GPCRs involved in chemotaxis. They are characterized by binding of N-formyl peptides which are produced by the degradation of bacteria or host cells. FP receptors have thus been implicated in the immune response to infections but they may also suppress the immune system in certain diseases. Therefore, both agonists and antagonists may be of therapeutic value.

In a screening of the PEM library for agonists and antagonists against both the FPR1 and FPR2 receptor, Polyphor has identified potent hits in the nanomolar range. These novel PEM molecules are currently further characterized before eventually entering lead optimization. Polyphor is currently actively seeking academic and Pharma partners for collaborations in this field.

Polyphor Ltd
Hegenheimermattweg 125
CH-4123 Allschwil
Switzerland
Tel. +41 61 567 16 00
Fax +41 61 567 16 01
info@polyphor.com

Last modified:   02.04.2013

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